Forex Market News Today
  • Home
  • News
  • LiveHourly
  • Markets
  • Stock
  • Business
  • Economy
  • World
  • Politics
  • Energy
  • exchange
  • companies
No Result
View All Result
Forex Market News Today
Home News

MacroGenics Presents Flotetuzumab Data in Patients with Refractory Acute Myeloid…

3 months ago
in News
2 min read
Live Foreign Currency Exchange Rates
Share on FacebookShare on Twitter


  • 31.8% CR/CRh/CRi rate in primary induction failure and early relapsed AML patients
  • Median duration of response = 8.13 months

ROCKVILLE, MD, Dec. 06, 2020 (GLOBE NEWSWIRE) —  

MacroGenics, Inc. (NASDAQ: MGNX), a clinical-stage biopharmaceutical company focused on discovering and developing innovative monoclonal antibody-based therapeutics for the treatment of cancer, today announced updated results from a single-arm, registrational study of flotetuzumab, an investigational, bispecific CD123 × CD3 DART® molecule, in patients with primary induction failure (PIF) and early relapsed (less than six months, or ER6) acute myeloid leukemia (AML). The data were presented at the 62nd Annual Meeting of the American Society of Hematology (ASH) taking place December 5-8, 2020.

In the open label study of flotetuzumab, 44 AML patients had disease classified as either PIF or ER6. Of these patients, 72.7% (32 of 44) had adverse risk cytogenetics by ELN Risk Stratification (2017). Patients were treated with flotetuzumab at the recommended Phase 2 dose (RP2D) of 500 ng/kg/day by continuous infusion. Data were reported as of the cut-off date of November 10, 2020. The study is currently ongoing, with a total of up to 200 patients planned for enrollment for registrational purposes.

The median time to achieve a response to flotetuzumab was one cycle (range of 1-3 cycles). Responses, including complete remission (CR), CRh (CR with partial hematological recovery) and CRi (CR with incomplete hematological improvement) per a modified International Working Group (IWG) Response Criteria for AML, are summarized in the table below.

  PIF/ER (n=44) PIF (n=27) ER6 (n=17)
CR/CRh 25.0% (11) 33.3% (9) 11.8% (2)
CR/CRh/Cri 31.8% (14) 37.0% (10) 23.5% (4)
HSCT 57.1% (8/14) 70.0% (7/10) 25.0% (1/4)
Median Duration of Response 8.13 mos.
(n=14)
15.2 mos.
(n=10)
2.4 mos.
(n=4)

As shown in the table, over 50% of responders (8 of 14) successfully received allogeneic hematopoietic stem cell transplantation (HSCT) as consolidation therapy with durable remission (median not reached). Also, among those PIF/ER6 patients who achieved remission (CR, CRh or CRi), the median duration of response was 8.13 months, with a median overall survival of 10.7 months. Within the PIF/ER6 population, five of ten patients with TP53MUT AML achieved CR/CRh/CRi responses, three of whom went on to receive HSCT. More detailed flotetuzumab clinical data in the TP53MUT AML population is available via a separate poster presentation at ASH (see “TP53 Abnormalities Correlate with Immune Infiltration and Associate with Response to Flotetuzumab Immunotherapy in Acute Myeloid Leukemia”, Session 617).

The most common treatment-related adverse event (TRAE) was infusion-related reaction/cytokine release syndrome (IRR/CRS), which occurred in all patients. However, most CRS events observed were of short duration and mild to moderate (Grade 1 or 2) in severity, with only a single Grade 3 event…



Go to the news source: MacroGenics Presents Flotetuzumab Data in Patients with Refractory Acute Myeloid…

Tags: AcuteDataFlotetuzumabMacroGenicsMyeloidPatientsPresentsRefractory
Previous Post

Brexit: Lambs to the slaughter – BBC News

Next Post

Could Investing in the Stock Market Be Part of Your Life?

Related Posts

Adial Receives $1.425 Million in Net Proceeds from Exercise of Warrants
News

Adial Receives $1.425 Million in Net Proceeds from Exercise of Warrants

by Forex News
February 26, 2021
0

CHARLOTTESVILLE, Va., Feb. 26, 2021 (GLOBE NEWSWIRE) — Adial Pharmaceuticals, Inc. (NASDAQ: ADIL; ADILW) (“Adial” or the “Company”), a...

Read more
New York and Tether Conclude a Settlement
News

New York and Tether Conclude a Settlement

by Forex News
February 26, 2021
0

USDT/USD has incrementally traded higher as a settlement has been reached between New York and Tether. Advertisement USDT/USD is...

Read more
NZD/USD Forecast: Most Overbought Since December
News

NZD/USD Forecast: Most Overbought Since December

by Forex News
February 25, 2021
0

The NZD/USD price is in a strong upsurge as investors react to the latest RBNZ interest rate decision and...

Read more
The NZDUSD attempts to recover – Analysis
News

Midday update for the NZDUSD 24-02-2021

by Forex News
February 24, 2021
0

The NZDUSD pair continues to provide the positive trades and attempts to crawl towards our waited target at 0.7400,...

Read more
Day Ahead Outlook Tech suffers as Oil and consumer stocks rally
News

Day Ahead Outlook Tech suffers as Oil and consumer stocks rally

by Forex News
February 23, 2021
0

Here is what you need to know on Tuesday, February 23: Update after the first hour of trading: It...

Read more
Avinash Singh Indicted For Over $57M In Investment Fraud
News

Avinash Singh Indicted For Over $57M In Investment Fraud

by Forex News
February 23, 2021
0

Operator Of Highrise Advantage, LLC, Avinash Singh Indicted For Over $57 Million In Investment Fraud Orlando, FL (STL.News) United...

Read more
The NZDUSD attempts to recover – Analysis
News

The USDCHF resumes the rise – Analysis

by Forex News
February 22, 2021
0

The USDCHF pair resumes its positive trading to start attempts to breach 0.8975 level, reinforcing the expectations of continuing...

Read more
Is Now The Time To Look At Buying Groupe Pizzorno Environnement (EPA:GPE)?
News

Is Now The Time To Look At Buying Groupe Pizzorno Environnement (EPA:GPE)?

by Forex News
February 21, 2021
0

Groupe Pizzorno Environnement (EPA:GPE), is not the largest company out there, but it led the ENXTPA gainers with a...

Read more
Astro Trading Discord Educational Community Helps Users Reach New Heights And Le…
News

Astro Trading Discord Educational Community Helps Users Reach New Heights And Le…

by Forex News
February 20, 2021
0

MANSFIELD, TX, USA, February 20, 2021 /EINPresswire.com/ -- It has been observed that 90%+ traders lose money, and roughly...

Read more
Mammoth Energy Announces Timing of 4Q and Full Year 2020 Earnings Release
News

Mammoth Energy Announces Timing of 4Q and Full Year 2020 Earnings Release

by Forex News
February 20, 2021
0

OKLAHOMA CITY, Feb. 19, 2021 (GLOBE NEWSWIRE) — Mammoth Energy Services, Inc. (“Mammoth”) (NASDAQ:TUSK) today announced that it intends...

Read more
Next Post
Could Investing in the Stock Market Be Part of Your Life?

Could Investing in the Stock Market Be Part of Your Life?

Subscribe
Login
Notify of
guest
guest
0 Comments
Inline Feedbacks
View all comments

Latest Forex News

Stock Market Rally, Tesla Stock Soar, But Flash Warning Signs; Micron Earnings, …

Stock Market Rally, Tesla Stock Soar, But Flash Warning Signs; Micron Earnings, …

2 months ago
French Fishermen Worry What A Trade Deal May Mean For Them : NPR

French Fishermen Worry What A Trade Deal May Mean For Them : NPR

2 months ago
Spot market carries momentum from Thanksgiving into December

Spot market carries momentum from Thanksgiving into December

3 months ago
Live Market Updates: Stocks Rise as Brexit Talks Are Extended

Live Market Updates: Stocks Rise as Brexit Talks Are Extended

2 months ago

Today Market News

Investors aren’t ‘stampeding’ out of gold because inflation is still a threat – …
Economy

Investors aren’t ‘stampeding’ out of gold because inflation is still a threat – …

February 26, 2021
Nigeria kidnappings: Gunmen abduct schoolgirls in Zamfara State, government offi…
World

Nigeria kidnappings: Gunmen abduct schoolgirls in Zamfara State, government offi…

February 26, 2021
US removes stumbling block to global deal on digital tax
Economy

US removes stumbling block to global deal on digital tax

February 26, 2021
Live updates: Biden to survey winter storm recovery in Texas; House poised to pa…
Politics

Live updates: Biden to survey winter storm recovery in Texas; House poised to pa…

February 26, 2021
Stock Market Rally Under Pressure As Tesla, Nvidia, Square, Growth Stocks Sell O…
Stock

Stock Market Rally Under Pressure As Tesla, Nvidia, Square, Growth Stocks Sell O…

February 26, 2021
Toothpaste in your tank – Hydrogen goop could be a more convenient fuel than hyd…
Energy

Toothpaste in your tank – Hydrogen goop could be a more convenient fuel than hyd…

February 26, 2021
  • Contact Us
  • Terms of Use
  • Privacy Policy
  • DMCA
  • CCPA

© 2020 Siteofforex.com

No Result
View All Result
  • Home
  • News
  • Live
  • Markets
  • Stock
  • Business
  • Economy
  • World
  • Politics
  • Energy
  • exchange
  • companies

© 2020 Siteofforex.com

wpDiscuz